# hmmsearch :: search profile(s) against a sequence database
# HMMER 3.0 (March 2010); http://hmmer.org/
# Copyright (C) 2010 Howard Hughes Medical Institute.
# Freely distributed under the GNU General Public License (GPLv3).
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
# query HMM file:                  mult.hmm
# target sequence database:        /home/bow/db/hmmer/uniprot_sprot.fasta
# output directed to file:         hmmer_cases/text_hmmsearch_mult.out
# per-seq hits tabular output:     hmmer_cases/tab_hmmsearch_mult.out
# per-dom hits tabular output:     hmmer_cases/domtab_hmmsearch_mult.out
# sequence reporting threshold:    score >= 480
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -

Query:       globins4  [M=149]
Scores for complete sequences (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Sequence Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each sequence (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query model(s):                            1  (149 nodes)
Target sequences:                     535698  (190107059 residues)
Passed MSV filter:                     20698  (0.0386374); expected 10714.0 (0.02)
Passed bias filter:                    16985  (0.0317063); expected 10714.0 (0.02)
Passed Vit filter:                      2311  (0.004314); expected 535.7 (0.001)
Passed Fwd filter:                      1104  (0.00206086); expected 5.4 (1e-05)
Initial search space (Z):             535698  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 14.07u 0.15s 00:00:14.22 Elapsed: 00:00:03.97
# Mc/sec: 7135.00
//
Query:       Pkinase  [M=260]
Accession:   PF00069.17
Description: Protein kinase domain
Scores for complete sequences (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Sequence              Description
    ------- ------ -----    ------- ------ -----   ---- --  --------              -----------
   8.4e-147  492.3   0.0    1.1e-72  249.3   0.0    2.1  2  sp|Q9WUT3|KS6A2_MOUSE Ribosomal protein S6 kinase alpha-2 OS
   2.7e-146  490.7   0.0    8.7e-73  249.7   0.0    2.1  2  sp|Q63531|KS6A1_RAT   Ribosomal protein S6 kinase alpha-1 OS
   2.2e-145  487.7   0.0    4.6e-72  247.4   0.0    2.1  2  sp|Q15418|KS6A1_HUMAN Ribosomal protein S6 kinase alpha-1 OS
   2.5e-145  487.5   0.0    7.5e-72  246.7   0.0    2.1  2  sp|P18652|KS6AA_CHICK Ribosomal protein S6 kinase 2 alpha OS
   2.4e-144  484.2   0.0    2.4e-70  241.7   0.0    2.1  2  sp|Q15349|KS6A2_HUMAN Ribosomal protein S6 kinase alpha-2 OS
     5e-144  483.2   0.0    3.9e-70  241.0   0.0    2.2  2  sp|P51812|KS6A3_HUMAN Ribosomal protein S6 kinase alpha-3 OS
     5e-144  483.2   0.0    3.9e-70  241.0   0.0    2.2  2  sp|P18654|KS6A3_MOUSE Ribosomal protein S6 kinase alpha-3 OS


Domain annotation for each sequence (and alignments):
>> sp|Q9WUT3|KS6A2_MOUSE  Ribosomal protein S6 kinase alpha-2 OS=Mus musculus GN=Rps6ka2 PE=2 SV=1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  241.2   0.0   4.6e-75   3.5e-70       1     260 []      59     318 ..      59     318 .. 0.95
   2 !  249.3   0.0   1.5e-77   1.1e-72       1     260 []     415     672 ..     415     672 .. 0.97

  Alignments for each domain:
  == domain 1    score: 241.2 bits;  conditional E-value: 4.6e-75
                            EEEEEEEEEETTEEEEEEEE...TTTTEEEEEEEEEHHHCCCCCCHHHHHHHHHHHHHSSSSB--EEEEEEETTEEEEEEE--TS-BH CS
                Pkinase   1 yelleklGsGsfGkVykakk...kktgkkvAvKilkkeeekskkektavrElkilkklsHpnivkllevfetkdelylvleyveggdl 85 
                            +ell+ lG+Gs+GkV+ ++k   ++ g+ +A+K+lkk + k + + +++ E  il++++Hp+ivkl+ +f+t+ +lyl+l++++ggdl
  sp|Q9WUT3|KS6A2_MOUSE  59 FELLKVLGQGSYGKVFLVRKvtgSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDL 146
                            67899**********7666611155667*****************99999************************************** PP

                            HHHHHHHHST-HHHHHHHHHHHHHHHHHHHHTTEE-S--SGGGEEEETTTEEEE--GTT.E..EECSS-C-S--S-GGGS-HHHHCCS CS
                Pkinase  86 fdllkkegklseeeikkialqilegleylHsngiiHrDLKpeNiLldkkgevkiaDFGlakkleksseklttlvgtreYmAPEvllka 173
                            f+ l+ke  ++ee++k+++ +++ +l++lH  gii+rDLKpeNiLld++g++ki+DFGl+k+++ +++++++++gt eYmAPEv++ +
  sp|Q9WUT3|KS6A2_MOUSE 147 FTRLSKEVMFTEEDVKFYLAELALALDHLHGLGIIYRDLKPENILLDEEGHIKITDFGLSKEATDHDKRAYSFCGTIEYMAPEVVN-R 233
                            **************************************************************************************.* PP

                            -CTHHHHHHHHHHHHHHHHHHSS-TTSSSHHCCTHHHHSSHHH......TTS.....HHHHHHHHHHT-SSGGGSTT.....HHHHHT CS
                Pkinase 174 keytkkvDvWslGvilyelltgklpfsgeseedqleliekilkkkleedepkssskseelkdlikkllekdpakRlt.....aeeilk 256
                            +++t+++D+Ws+Gv+++e+ltg+lpf+g+   d++e+++ ilk kl  ++  s    +e+++l++ l++++p +Rl      +eei++
  sp|Q9WUT3|KS6A2_MOUSE 234 RGHTQSADWWSFGVLMFEMLTGSLPFQGK---DRKETMALILKAKLGMPQFLS----AEAQSLLRALFKRNPCNRLGagvdgVEEIKR 314
                            *****************************...999999999999999998866....99******************9999999**** PP

                            SGGG CS
                Pkinase 257 hpwl 260
                            hp++
  sp|Q9WUT3|KS6A2_MOUSE 315 HPFF 318
                            *997 PP

  == domain 2    score: 249.3 bits;  conditional E-value: 1.5e-77
                            EEEEEEEEEETTEEEEEEEETTTTEEEEEEEEEHHHCCCCCCHHHHHHHHHHHHH.SSSSB--EEEEEEETTEEEEEEE--TS-BHHH CS
                Pkinase   1 yelleklGsGsfGkVykakkkktgkkvAvKilkkeeekskkektavrElkilkkl.sHpnivkllevfetkdelylvleyveggdlfd 87 
                            ye++e +G Gs+++++++++k t  ++AvKi++k++++ ++      E++il +  +Hpni++l +v+ + +++ylv+e+++gg+l d
  sp|Q9WUT3|KS6A2_MOUSE 415 YEIKEDIGVGSYSVCKRCVHKATDAEYAVKIIDKSKRDPSE------EIEILLRYgQHPNIITLKDVYDDGKYVYLVMELMRGGELLD 496
                            7899***********************************98......9*******99******************************* PP

                            HHHHHHST-HHHHHHHHHHHHHHHHHHHHTTEE-S--SGGGEEEETTTEE....EE--GTT.E..EECSS-C-S--S-GGGS-HHHHC CS
                Pkinase  88 llkkegklseeeikkialqilegleylHsngiiHrDLKpeNiLldkkgev....kiaDFGlakkleksseklttlvgtreYmAPEvll 171
                             + +++++se+e+ +++++i++ ++ylHs+g++HrDLKp+NiL  +++      +i+DFG+ak+l  +++ l t + t +++APEvl+
  sp|Q9WUT3|KS6A2_MOUSE 497 RILRQRCFSEREASDVLYTIARTMDYLHSQGVVHRDLKPSNILYMDESGNpesiRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLK 584
                            *******************************************98544444888********************************** PP

                            CS-CTHHHHHHHHHHHHHHHHHHSS-TTSSSHHCCTHHHHSSHHH......TTS.....HHHHHHHHHHT-SSGGGSTTHHHHHTSGG CS
                Pkinase 172 kakeytkkvDvWslGvilyelltgklpfsgeseedqleliekilkkkleedepkssskseelkdlikkllekdpakRltaeeilkhpw 259
                             +++y++++DvWslG++ly++l g +pf +  +++ +e++++i ++k+  +  +++s s+ +kd+++k+l+ dp++Rlta ++lkhpw
  sp|Q9WUT3|KS6A2_MOUSE 585 -RQGYDAACDVWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPQQRLTAVQVLKHPW 671
                            .*************************************************************************************** PP

                            G CS
                Pkinase 260 l 260
                            +
  sp|Q9WUT3|KS6A2_MOUSE 672 I 672
                            7 PP

>> sp|Q63531|KS6A1_RAT  Ribosomal protein S6 kinase alpha-1 OS=Rattus norvegicus GN=Rps6ka1 PE=1 SV=1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  239.2   0.0   1.9e-74   1.4e-69       1     258 [.      62     319 ..      62     321 .. 0.94
   2 !  249.7   0.0   1.1e-77   8.7e-73       2     260 .]     419     675 ..     418     675 .. 0.97

  Alignments for each domain:
  == domain 1    score: 239.2 bits;  conditional E-value: 1.9e-74
                          EEEEEEEEEETTEEE...EEEEETTTTEEEEEEEEEHHHCCCCCCHHHHHHHHHHHHHSSSSB--EEEEEEETTEEEEEEE--TS-BHHH CS
              Pkinase   1 yelleklGsGsfGkV...ykakkkktgkkvAvKilkkeeekskkektavrElkilkklsHpnivkllevfetkdelylvleyveggdlfd 87 
                          +ell+ lG+GsfGkV    k+++ ++g+ +A+K+lkk + k + + +++ E  il+ ++Hp++vkl+ +f+t+ +lyl+l++++ggdlf+
  sp|Q63531|KS6A1_RAT  62 FELLKVLGQGSFGKVflvRKVTRPDNGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFT 151
                          67899**********4444555666777****************999999**************************************** PP

                          HHHHHHST-HHHHHHHHHHHHHHHHHHHHTTEE-S--SGGGEEEETTTEEEE--GTT.E..EECSS-C-S--S-GGGS-HHHHCCS-CTH CS
              Pkinase  88 llkkegklseeeikkialqilegleylHsngiiHrDLKpeNiLldkkgevkiaDFGlakkleksseklttlvgtreYmAPEvllkakeyt 177
                           l+ke  ++ee++k+++ +++ gl++lHs gii+rDLKpeNiLld++g++k++DFGl+k++  +++k+++++gt eYmAPEv++ ++++t
  sp|Q63531|KS6A1_RAT 152 RLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVN-RQGHT 240
                          ************************************************************************************.***** PP

                          HHHHHHHHHHHHHHHHHSS-TTSSSHHCCTHHHHSSHHH......TTS.....HHHHHHHHHHT-SSGGGSTT.....HHHHHTSG CS
              Pkinase 178 kkvDvWslGvilyelltgklpfsgeseedqleliekilkkkleedepkssskseelkdlikkllekdpakRlt.....aeeilkhp 258
                          +++D+Ws+Gv+++e+ltg+lpf+g+   d++e++  ilk kl  ++  s    +e+++l++ l++++pa+Rl      aeei++h 
  sp|Q63531|KS6A1_RAT 241 HSADWWSYGVLMFEMLTGSLPFQGK---DRKETMTLILKAKLGMPQFLS----TEAQSLLRALFKRNPANRLGsgpdgAEEIKRHI 319
                          *************************...999999999999999998866....89*****************98888888888885 PP

  == domain 2    score: 249.7 bits;  conditional E-value: 1.1e-77
                          EEEEEEEEETTEEEEEEEETTTTEEEEEEEEEHHHCCCCCCHHHHHHHHHHHHH.SSSSB--EEEEEEETTEEEEEEE--TS-BHHHHHH CS
              Pkinase   2 elleklGsGsfGkVykakkkktgkkvAvKilkkeeekskkektavrElkilkkl.sHpnivkllevfetkdelylvleyveggdlfdllk 90 
                           ++e++G Gs+++++++++k t+ ++AvK+++k++++ ++      E++il +  +Hpni++l +v+ +++++ylv+e+++gg+l d + 
  sp|Q63531|KS6A1_RAT 419 IVKETIGVGSYSVCKRCVHKATNMEYAVKVIDKSKRDPSE------EIEILLRYgQHPNIITLKDVYDDSKHVYLVTELMRGGELLDKIL 502
                          6789**********************************98......9*******99********************************** PP

                          HHHST-HHHHHHHHHHHHHHHHHHHHTTEE-S--SGGGEEEETTTEE....EE--GTT.E..EECSS-C-S--S-GGGS-HHHHCCS-CT CS
              Pkinase  91 kegklseeeikkialqilegleylHsngiiHrDLKpeNiLldkkgev....kiaDFGlakkleksseklttlvgtreYmAPEvllkakey 176
                          +++ +se+e+ +++++i + +eylHs+g++HrDLKp+NiL  +++      +i+DFG+ak+l  +++ l t + t +++APEvl+ +++y
  sp|Q63531|KS6A1_RAT 503 RQKFFSEREASFVLYTISKTVEYLHSQGVVHRDLKPSNILYVDESGNpeclRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLK-RQGY 591
                          9***************************************98554445999**********************************.**** PP

                          HHHHHHHHHHHHHHHHHHSS-TTSSSHHCCTHHHHSSHHH......TTS.....HHHHHHHHHHT-SSGGGSTTHHHHHTSGGG CS
              Pkinase 177 tkkvDvWslGvilyelltgklpfsgeseedqleliekilkkkleedepkssskseelkdlikkllekdpakRltaeeilkhpwl 260
                          ++ +D+WslGv+ly++l g +pf +  +++ +e++ +i+++k   +  ++++ se++kdl++k+l+ dp++Rlta+++l+hpw+
  sp|Q63531|KS6A1_RAT 592 DEGCDIWSLGVLLYTMLAGYTPFANGPSDTPEEILTRISSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWI 675
                          ***********************************************************************************7 PP

>> sp|Q15418|KS6A1_HUMAN  Ribosomal protein S6 kinase alpha-1 OS=Homo sapiens GN=RPS6KA1 PE=1 SV=2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  238.6   0.0   2.9e-74   2.2e-69       1     258 [.      62     319 ..      62     321 .. 0.94
   2 !  247.4   0.0     6e-77   4.6e-72       1     260 []     418     675 ..     418     675 .. 0.97

  Alignments for each domain:
  == domain 1    score: 238.6 bits;  conditional E-value: 2.9e-74
                            EEEEEEEEEETTEEE...EEEEETTTTEEEEEEEEEHHHCCCCCCHHHHHHHHHHHHHSSSSB--EEEEEEETTEEEEEEE--TS-BH CS
                Pkinase   1 yelleklGsGsfGkV...ykakkkktgkkvAvKilkkeeekskkektavrElkilkklsHpnivkllevfetkdelylvleyveggdl 85 
                            +ell+ lG+GsfGkV    k+++ ++g+ +A+K+lkk + k + + +++ E  il+ ++Hp++vkl+ +f+t+ +lyl+l++++ggdl
  sp|Q15418|KS6A1_HUMAN  62 FELLKVLGQGSFGKVflvRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDL 149
                            67899**********4444555566667****************999999************************************** PP

                            HHHHHHHHST-HHHHHHHHHHHHHHHHHHHHTTEE-S--SGGGEEEETTTEEEE--GTT.E..EECSS-C-S--S-GGGS-HHHHCCS CS
                Pkinase  86 fdllkkegklseeeikkialqilegleylHsngiiHrDLKpeNiLldkkgevkiaDFGlakkleksseklttlvgtreYmAPEvllka 173
                            f+ l+ke  ++ee++k+++ +++ gl++lHs gii+rDLKpeNiLld++g++k++DFGl+k++  +++k+++++gt eYmAPEv++ +
  sp|Q15418|KS6A1_HUMAN 150 FTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVN-R 236
                            **************************************************************************************.* PP

                            -CTHHHHHHHHHHHHHHHHHHSS-TTSSSHHCCTHHHHSSHHH......TTS.....HHHHHHHHHHT-SSGGGSTT.....HHHHHT CS
                Pkinase 174 keytkkvDvWslGvilyelltgklpfsgeseedqleliekilkkkleedepkssskseelkdlikkllekdpakRlt.....aeeilk 256
                            +++++++D+Ws+Gv+++e+ltg+lpf+g+   d++e++  ilk kl  ++  s    +e+++l++ l++++pa+Rl      aeei++
  sp|Q15418|KS6A1_HUMAN 237 QGHSHSADWWSYGVLMFEMLTGSLPFQGK---DRKETMTLILKAKLGMPQFLS----TEAQSLLRALFKRNPANRLGsgpdgAEEIKR 317
                            *****************************...999999999999999998866....89*****************988888899888 PP

                            SG CS
                Pkinase 257 hp 258
                            h 
  sp|Q15418|KS6A1_HUMAN 318 HV 319
                            85 PP

  == domain 2    score: 247.4 bits;  conditional E-value: 6e-77
                            EEEEEEEEEETTEEEEEEEETTTTEEEEEEEEEHHHCCCCCCHHHHHHHHHHHHH.SSSSB--EEEEEEETTEEEEEEE--TS-BHHH CS
                Pkinase   1 yelleklGsGsfGkVykakkkktgkkvAvKilkkeeekskkektavrElkilkkl.sHpnivkllevfetkdelylvleyveggdlfd 87 
                            y ++e++G Gs+++++++++k t+ ++AvK+++k++++ ++      E++il +  +Hpni++l +v+ + +++ylv+e+++gg+l d
  sp|Q15418|KS6A1_HUMAN 418 YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSE------EIEILLRYgQHPNIITLKDVYDDGKHVYLVTELMRGGELLD 499
                            67899**********************************98......9*******99******************************* PP

                            HHHHHHST-HHHHHHHHHHHHHHHHHHHHTTEE-S--SGGGEEEETTTEE....EE--GTT.E..EECSS-C-S--S-GGGS-HHHHC CS
                Pkinase  88 llkkegklseeeikkialqilegleylHsngiiHrDLKpeNiLldkkgev....kiaDFGlakkleksseklttlvgtreYmAPEvll 171
                             + +++ +se+e+ +++ +i + +eylHs+g++HrDLKp+NiL  +++      +i+DFG+ak+l  +++ l t + t +++APEvl+
  sp|Q15418|KS6A1_HUMAN 500 KILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNpeclRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLK 587
                            ***9***************************************98554445999********************************** PP

                            CS-CTHHHHHHHHHHHHHHHHHHSS-TTSSSHHCCTHHHHSSHHH......TTS.....HHHHHHHHHHT-SSGGGSTTHHHHHTSGG CS
                Pkinase 172 kakeytkkvDvWslGvilyelltgklpfsgeseedqleliekilkkkleedepkssskseelkdlikkllekdpakRltaeeilkhpw 259
                             +++y++ +D+WslG++ly++l g +pf +  +++ +e++ +i ++k   +  ++++ se++kdl++k+l+ dp++Rlta+++l+hpw
  sp|Q15418|KS6A1_HUMAN 588 -RQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPW 674
                            .*************************************************************************************** PP

                            G CS
                Pkinase 260 l 260
                            +
  sp|Q15418|KS6A1_HUMAN 675 V 675
                            6 PP

>> sp|P18652|KS6AA_CHICK  Ribosomal protein S6 kinase 2 alpha OS=Gallus gallus GN=RPS6KA PE=2 SV=1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  239.0   0.0   2.1e-74   1.6e-69       1     259 [.      80     338 ..      80     339 .. 0.95
   2 !  246.7   0.0   9.8e-77   7.5e-72       1     260 []     435     692 ..     435     692 .. 0.97

  Alignments for each domain:
  == domain 1    score: 239.0 bits;  conditional E-value: 2.1e-74
                            EEEEEEEEEETTEEEEEEEET...TTTEEEEEEEEEHHHCCCCCCHHHHHHHHHHHHHSSSSB--EEEEEEETTEEEEEEE--TS-BH CS
                Pkinase   1 yelleklGsGsfGkVykakkk...ktgkkvAvKilkkeeekskkektavrElkilkklsHpnivkllevfetkdelylvleyveggdl 85 
                            +ell+ lG+GsfGkV+ ++k    ++++ +A+K+lkk + k + + +++ E  il+ ++Hp++vkl+ +f+t+ +lyl+l++++ggdl
  sp|P18652|KS6AA_CHICK  80 FELLKVLGQGSFGKVFLVRKItppDSNHLYAMKVLKKATLKVRDRVRTKIERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDL 167
                            67899**********7777661115677**************99999888************************************** PP

                            HHHHHHHHST-HHHHHHHHHHHHHHHHHHHHTTEE-S--SGGGEEEETTTEEEE--GTT.E..EECSS-C-S--S-GGGS-HHHHCCS CS
                Pkinase  86 fdllkkegklseeeikkialqilegleylHsngiiHrDLKpeNiLldkkgevkiaDFGlakkleksseklttlvgtreYmAPEvllka 173
                            f+ l+ke  ++ee++k+++ +++ gl++lHs gii+rDLKpeNiLld++g++k++DFGl+k++  +++k+++++gt eYmAPEv++ +
  sp|P18652|KS6AA_CHICK 168 FTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVN-R 254
                            **************************************************************************************.* PP

                            -CTHHHHHHHHHHHHHHHHHHSS-TTSSSHHCCTHHHHSSHHH......TTS.....HHHHHHHHHHT-SSGGGSTT.....HHHHHT CS
                Pkinase 174 keytkkvDvWslGvilyelltgklpfsgeseedqleliekilkkkleedepkssskseelkdlikkllekdpakRlt.....aeeilk 256
                            +++++++D+Ws+Gv+++e+ltg+lpf+g+   d++e++  ilk kl  ++  s    +e+++l++ l++++pa+Rl      aeei++
  sp|P18652|KS6AA_CHICK 255 QGHSHSADWWSYGVLMFEMLTGSLPFQGK---DRKETMTLILKAKLGMPQFLS----AEAQSLLRALFKRNPANRLGsgpdgAEEIKR 335
                            *****************************...999999999999999998866....99*****************999999****** PP

                            SGG CS
                Pkinase 257 hpw 259
                            hp+
  sp|P18652|KS6AA_CHICK 336 HPF 338
                            *98 PP

  == domain 2    score: 246.7 bits;  conditional E-value: 9.8e-77
                            EEEEEEEEEETTEEEEEEEETTTTEEEEEEEEEHHHCCCCCCHHHHHHHHHHHHH.SSSSB--EEEEEEETTEEEEEEE--TS-BHHH CS
                Pkinase   1 yelleklGsGsfGkVykakkkktgkkvAvKilkkeeekskkektavrElkilkkl.sHpnivkllevfetkdelylvleyveggdlfd 87 
                            y ++e +G Gs+++++++++k+t+ ++AvK+++k++++ ++      E++il +  +Hpni++l +v+ + +++ylv+e+++gg+l d
  sp|P18652|KS6AA_CHICK 435 YVVKEAIGVGSYSVCKRCIHKTTNMEYAVKVIDKSKRDPSE------EIEILLRYgQHPNIITLKDVYDDGKYVYLVTELMRGGELLD 516
                            568899*********************************98......9*******99******************************* PP

                            HHHHHHST-HHHHHHHHHHHHHHHHHHHHTTEE-S--SGGGEEEETTTEE....EE--GTT.E..EECSS-C-S--S-GGGS-HHHHC CS
                Pkinase  88 llkkegklseeeikkialqilegleylHsngiiHrDLKpeNiLldkkgev....kiaDFGlakkleksseklttlvgtreYmAPEvll 171
                             + +++ +se+e+ +++ +i++ +eylHs+g++HrDLKp+NiL  +++      +i+DFG+ak+l  +++ l t + t +++APEvl+
  sp|P18652|KS6AA_CHICK 517 KILRQKFFSEREASSVLHTICKTVEYLHSQGVVHRDLKPSNILYVDESGNpesiRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLK 604
                            ***9***************************************98554444888********************************** PP

                            CS-CTHHHHHHHHHHHHHHHHHHSS-TTSSSHHCCTHHHHSSHHH......TTS.....HHHHHHHHHHT-SSGGGSTTHHHHHTSGG CS
                Pkinase 172 kakeytkkvDvWslGvilyelltgklpfsgeseedqleliekilkkkleedepkssskseelkdlikkllekdpakRltaeeilkhpw 259
                             +++y++ +D+WslGv+ly++l g++pf +  +++ +e++ +i ++k + +  ++++ s+ +kdl++k+l+ dp++Rlta+++l+hpw
  sp|P18652|KS6AA_CHICK 605 -RQGYDEGCDIWSLGVLLYTMLAGCTPFANGPSDTPEEILTRIGGGKFSVNGGNWDTISDVAKDLVSKMLHVDPHQRLTAKQVLQHPW 691
                            .*************************************************************************************** PP

                            G CS
                Pkinase 260 l 260
                            +
  sp|P18652|KS6AA_CHICK 692 I 692
                            7 PP

>> sp|Q15349|KS6A2_HUMAN  Ribosomal protein S6 kinase alpha-2 OS=Homo sapiens GN=RPS6KA2 PE=1 SV=2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  241.7   0.0   3.2e-75   2.4e-70       1     260 []      59     318 ..      59     318 .. 0.95
   2 !  240.7   0.0   6.4e-75   4.9e-70       1     260 []     415     672 ..     415     672 .. 0.97

  Alignments for each domain:
  == domain 1    score: 241.7 bits;  conditional E-value: 3.2e-75
                            EEEEEEEEEETTEEEEEEEETTTTE...EEEEEEEEHHHCCCCCCHHHHHHHHHHHHHSSSSB--EEEEEEETTEEEEEEE--TS-BH CS
                Pkinase   1 yelleklGsGsfGkVykakkkktgk...kvAvKilkkeeekskkektavrElkilkklsHpnivkllevfetkdelylvleyveggdl 85 
                            +ell+ lG+Gs+GkV+ ++k k ++    +A+K+lkk + k + + +++ E  il++++Hp+ivkl+ +f+t+ +lyl+l++++ggdl
  sp|Q15349|KS6A2_HUMAN  59 FELLKVLGQGSYGKVFLVRKVKGSDagqLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDL 146
                            67899**********7777665544444*****************99999************************************** PP

                            HHHHHHHHST-HHHHHHHHHHHHHHHHHHHHTTEE-S--SGGGEEEETTTEEEE--GTT.E..EECSS-C-S--S-GGGS-HHHHCCS CS
                Pkinase  86 fdllkkegklseeeikkialqilegleylHsngiiHrDLKpeNiLldkkgevkiaDFGlakkleksseklttlvgtreYmAPEvllka 173
                            f+ l+ke  ++ee++k+++ +++ +l++lHs gii+rDLKpeNiLld++g++ki+DFGl+k++  +++++++++gt eYmAPEv++ +
  sp|Q15349|KS6A2_HUMAN 147 FTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVN-R 233
                            **************************************************************************************.* PP

                            -CTHHHHHHHHHHHHHHHHHHSS-TTSSSHHCCTHHHHSSHHH......TTS.....HHHHHHHHHHT-SSGGGSTT.....HHHHHT CS
                Pkinase 174 keytkkvDvWslGvilyelltgklpfsgeseedqleliekilkkkleedepkssskseelkdlikkllekdpakRlt.....aeeilk 256
                            +++t+++D+Ws+Gv+++e+ltg+lpf+g+   d++e+++ ilk kl  ++  s     e+++l++ l++++p +Rl      +eei++
  sp|Q15349|KS6A2_HUMAN 234 RGHTQSADWWSFGVLMFEMLTGSLPFQGK---DRKETMALILKAKLGMPQFLS----GEAQSLLRALFKRNPCNRLGagidgVEEIKR 314
                            *****************************...999999999999999888866....89******************9999999**** PP

                            SGGG CS
                Pkinase 257 hpwl 260
                            hp++
  sp|Q15349|KS6A2_HUMAN 315 HPFF 318
                            *997 PP

  == domain 2    score: 240.7 bits;  conditional E-value: 6.4e-75
                            EEEEEEEEEETTEEEEEEEETTTTEEEEEEEEEHHHCCCCCCHHHHHHHHHHHHH.SSSSB--EEEEEEETTEEEEEEE--TS-BHHH CS
                Pkinase   1 yelleklGsGsfGkVykakkkktgkkvAvKilkkeeekskkektavrElkilkkl.sHpnivkllevfetkdelylvleyveggdlfd 87 
                            ye++e +G Gs+++++++++k t +++AvKi++k++++ ++      E++il +  +Hpni++l +v+ + + +ylv+e+++gg+l d
  sp|Q15349|KS6A2_HUMAN 415 YEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSE------EIEILLRYgQHPNIITLKDVYDDGKFVYLVMELMRGGELLD 496
                            7899***********************************98......9*******99******************************* PP

                            HHHHHHST-HHHHHHHHHHHHHHHHHHHHTTEE-S--SGGGEEEETTTEE....EE--GTT.E..EECSS-C-S--S-GGGS-HHHHC CS
                Pkinase  88 llkkegklseeeikkialqilegleylHsngiiHrDLKpeNiLldkkgev....kiaDFGlakkleksseklttlvgtreYmAPEvll 171
                             + +++ +se+e+ +++ +i + ++ylHs+g++HrDLKp+NiL  +++      +++DFG+ak+l   ++ l t + t +++APEvl+
  sp|Q15349|KS6A2_HUMAN 497 RILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSpesiRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLK 584
                            ********************************************9554445888********************************** PP

                            CS-CTHHHHHHHHHHHHHHHHHHSS-TTSSSHHCCTHHHHSSHHH......TTS.....HHHHHHHHHHT-SSGGGSTTHHHHHTSGG CS
                Pkinase 172 kakeytkkvDvWslGvilyelltgklpfsgeseedqleliekilkkkleedepkssskseelkdlikkllekdpakRltaeeilkhpw 259
                             +++y++++D+WslG++ly++l g +pf +  +++ +e++++i ++k+  +  +++s s+ +kd+++k+l+ dp++Rlta+++lkhpw
  sp|Q15349|KS6A2_HUMAN 585 -RQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHPW 671
                            .*************************************************************************************** PP

                            G CS
                Pkinase 260 l 260
                            +
  sp|Q15349|KS6A2_HUMAN 672 V 672
                            6 PP

>> sp|P51812|KS6A3_HUMAN  Ribosomal protein S6 kinase alpha-3 OS=Homo sapiens GN=RPS6KA3 PE=1 SV=1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  240.3   0.0   8.7e-75   6.6e-70       1     260 []      68     327 ..      68     327 .. 0.95
   2 !  241.0   0.0   5.1e-75   3.9e-70       1     260 []     422     679 ..     422     679 .. 0.97

  Alignments for each domain:
  == domain 1    score: 240.3 bits;  conditional E-value: 8.7e-75
                            EEEEEEEEEETTEEEEEEEETTTTE...EEEEEEEEHHHCCCCCCHHHHHHHHHHHHHSSSSB--EEEEEEETTEEEEEEE--TS-BH CS
                Pkinase   1 yelleklGsGsfGkVykakkkktgk...kvAvKilkkeeekskkektavrElkilkklsHpnivkllevfetkdelylvleyveggdl 85 
                            +ell+ lG+GsfGkV+ +kk + ++    +A+K+lkk + k + + +++ E  il +++Hp+ivkl+ +f+t+ +lyl+l++++ggdl
  sp|P51812|KS6A3_HUMAN  68 FELLKVLGQGSFGKVFLVKKISGSDarqLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDL 155
                            67899**********8888876655455****************999999************************************** PP

                            HHHHHHHHST-HHHHHHHHHHHHHHHHHHHHTTEE-S--SGGGEEEETTTEEEE--GTT.E..EECSS-C-S--S-GGGS-HHHHCCS CS
                Pkinase  86 fdllkkegklseeeikkialqilegleylHsngiiHrDLKpeNiLldkkgevkiaDFGlakkleksseklttlvgtreYmAPEvllka 173
                            f+ l+ke  ++ee++k+++ +++ +l++lHs gii+rDLKpeNiLld++g++k++DFGl+k+   +++k+++++gt eYmAPEv++ +
  sp|P51812|KS6A3_HUMAN 156 FTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVN-R 242
                            **************************************************************9***********************.* PP

                            -CTHHHHHHHHHHHHHHHHHHSS-TTSSSHHCCTHHHHSSHHH......TTS.....HHHHHHHHHHT-SSGGGSTT.....HHHHHT CS
                Pkinase 174 keytkkvDvWslGvilyelltgklpfsgeseedqleliekilkkkleedepkssskseelkdlikkllekdpakRlt.....aeeilk 256
                            +++t+++D+Ws+Gv+++e+ltg+lpf+g+   d++e++ +ilk kl  ++  s    +e+++l++ l++++pa+Rl      +eei++
  sp|P51812|KS6A3_HUMAN 243 RGHTQSADWWSFGVLMFEMLTGTLPFQGK---DRKETMTMILKAKLGMPQFLS----PEAQSLLRMLFKRNPANRLGagpdgVEEIKR 323
                            *****************************...999999999999988888866....9******************988888899999 PP

                            SGGG CS
                Pkinase 257 hpwl 260
                            h+++
  sp|P51812|KS6A3_HUMAN 324 HSFF 327
                            9886 PP

  == domain 2    score: 241.0 bits;  conditional E-value: 5.1e-75
                            EEEEEEEEEETTEEEEEEEETTTTEEEEEEEEEHHHCCCCCCHHHHHHHHHHHHH.SSSSB--EEEEEEETTEEEEEEE--TS-BHHH CS
                Pkinase   1 yelleklGsGsfGkVykakkkktgkkvAvKilkkeeekskkektavrElkilkkl.sHpnivkllevfetkdelylvleyveggdlfd 87 
                            ye++e +G Gs+++++++++k t+ ++AvKi++k++++ ++      E++il +  +Hpni++l +v+ + +++y+v+e+++gg+l d
  sp|P51812|KS6A3_HUMAN 422 YEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTE------EIEILLRYgQHPNIITLKDVYDDGKYVYVVTELMKGGELLD 503
                            7899***********************************88......9*******99******************************* PP

                            HHHHHHST-HHHHHHHHHHHHHHHHHHHHTTEE-S--SGGGEEEETTTEE....EE--GTT.E..EECSS-C-S--S-GGGS-HHHHC CS
                Pkinase  88 llkkegklseeeikkialqilegleylHsngiiHrDLKpeNiLldkkgev....kiaDFGlakkleksseklttlvgtreYmAPEvll 171
                             + +++ +se+e+  ++ +i + +eylH +g++HrDLKp+NiL  +++      +i+DFG+ak+l  +++ l t + t +++APEvl+
  sp|P51812|KS6A3_HUMAN 504 KILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNpesiRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLK 591
                            ***9***************************************98554444888********************************** PP

                            CS-CTHHHHHHHHHHHHHHHHHHSS-TTSSSHHCCTHHHHSSHHH......TTS.....HHHHHHHHHHT-SSGGGSTTHHHHHTSGG CS
                Pkinase 172 kakeytkkvDvWslGvilyelltgklpfsgeseedqleliekilkkkleedepkssskseelkdlikkllekdpakRltaeeilkhpw 259
                             +++y++++D+WslGv+ly++ltg +pf +  +++ +e++++i ++k + +   ++s s+++kdl++k+l+ dp++Rlta+ +l+hpw
  sp|P51812|KS6A3_HUMAN 592 -RQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPW 678
                            .*************************************************************************************** PP

                            G CS
                Pkinase 260 l 260
                            +
  sp|P51812|KS6A3_HUMAN 679 I 679
                            7 PP

>> sp|P18654|KS6A3_MOUSE  Ribosomal protein S6 kinase alpha-3 OS=Mus musculus GN=Rps6ka3 PE=1 SV=2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  240.3   0.0   8.7e-75   6.6e-70       1     260 []      68     327 ..      68     327 .. 0.95
   2 !  241.0   0.0   5.1e-75   3.9e-70       1     260 []     422     679 ..     422     679 .. 0.97

  Alignments for each domain:
  == domain 1    score: 240.3 bits;  conditional E-value: 8.7e-75
                            EEEEEEEEEETTEEEEEEEETTTTE...EEEEEEEEHHHCCCCCCHHHHHHHHHHHHHSSSSB--EEEEEEETTEEEEEEE--TS-BH CS
                Pkinase   1 yelleklGsGsfGkVykakkkktgk...kvAvKilkkeeekskkektavrElkilkklsHpnivkllevfetkdelylvleyveggdl 85 
                            +ell+ lG+GsfGkV+ +kk + ++    +A+K+lkk + k + + +++ E  il +++Hp+ivkl+ +f+t+ +lyl+l++++ggdl
  sp|P18654|KS6A3_MOUSE  68 FELLKVLGQGSFGKVFLVKKISGSDarqLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDL 155
                            67899**********8888876655455****************999999************************************** PP

                            HHHHHHHHST-HHHHHHHHHHHHHHHHHHHHTTEE-S--SGGGEEEETTTEEEE--GTT.E..EECSS-C-S--S-GGGS-HHHHCCS CS
                Pkinase  86 fdllkkegklseeeikkialqilegleylHsngiiHrDLKpeNiLldkkgevkiaDFGlakkleksseklttlvgtreYmAPEvllka 173
                            f+ l+ke  ++ee++k+++ +++ +l++lHs gii+rDLKpeNiLld++g++k++DFGl+k+   +++k+++++gt eYmAPEv++ +
  sp|P18654|KS6A3_MOUSE 156 FTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVN-R 242
                            **************************************************************9***********************.* PP

                            -CTHHHHHHHHHHHHHHHHHHSS-TTSSSHHCCTHHHHSSHHH......TTS.....HHHHHHHHHHT-SSGGGSTT.....HHHHHT CS
                Pkinase 174 keytkkvDvWslGvilyelltgklpfsgeseedqleliekilkkkleedepkssskseelkdlikkllekdpakRlt.....aeeilk 256
                            +++t+++D+Ws+Gv+++e+ltg+lpf+g+   d++e++ +ilk kl  ++  s    +e+++l++ l++++pa+Rl      +eei++
  sp|P18654|KS6A3_MOUSE 243 RGHTQSADWWSFGVLMFEMLTGTLPFQGK---DRKETMTMILKAKLGMPQFLS----PEAQSLLRMLFKRNPANRLGagpdgVEEIKR 323
                            *****************************...999999999999988888866....9******************988888899999 PP

                            SGGG CS
                Pkinase 257 hpwl 260
                            h+++
  sp|P18654|KS6A3_MOUSE 324 HSFF 327
                            9886 PP

  == domain 2    score: 241.0 bits;  conditional E-value: 5.1e-75
                            EEEEEEEEEETTEEEEEEEETTTTEEEEEEEEEHHHCCCCCCHHHHHHHHHHHHH.SSSSB--EEEEEEETTEEEEEEE--TS-BHHH CS
                Pkinase   1 yelleklGsGsfGkVykakkkktgkkvAvKilkkeeekskkektavrElkilkkl.sHpnivkllevfetkdelylvleyveggdlfd 87 
                            ye++e +G Gs+++++++++k t+ ++AvKi++k++++ ++      E++il +  +Hpni++l +v+ + +++y+v+e+++gg+l d
  sp|P18654|KS6A3_MOUSE 422 YEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTE------EIEILLRYgQHPNIITLKDVYDDGKYVYVVTELMKGGELLD 503
                            7899***********************************88......9*******99******************************* PP

                            HHHHHHST-HHHHHHHHHHHHHHHHHHHHTTEE-S--SGGGEEEETTTEE....EE--GTT.E..EECSS-C-S--S-GGGS-HHHHC CS
                Pkinase  88 llkkegklseeeikkialqilegleylHsngiiHrDLKpeNiLldkkgev....kiaDFGlakkleksseklttlvgtreYmAPEvll 171
                             + +++ +se+e+  ++ +i + +eylH +g++HrDLKp+NiL  +++      +i+DFG+ak+l  +++ l t + t +++APEvl+
  sp|P18654|KS6A3_MOUSE 504 KILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNpesiRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLK 591
                            ***9***************************************98554444888********************************** PP

                            CS-CTHHHHHHHHHHHHHHHHHHSS-TTSSSHHCCTHHHHSSHHH......TTS.....HHHHHHHHHHT-SSGGGSTTHHHHHTSGG CS
                Pkinase 172 kakeytkkvDvWslGvilyelltgklpfsgeseedqleliekilkkkleedepkssskseelkdlikkllekdpakRltaeeilkhpw 259
                             +++y++++D+WslGv+ly++ltg +pf +  +++ +e++++i ++k + +   ++s s+++kdl++k+l+ dp++Rlta+ +l+hpw
  sp|P18654|KS6A3_MOUSE 592 -RQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPW 678
                            .*************************************************************************************** PP

                            G CS
                Pkinase 260 l 260
                            +
  sp|P18654|KS6A3_MOUSE 679 I 679
                            7 PP



Internal pipeline statistics summary:
-------------------------------------
Query model(s):                            1  (260 nodes)
Target sequences:                     535698  (190107059 residues)
Passed MSV filter:                     21115  (0.0394159); expected 10714.0 (0.02)
Passed bias filter:                    15859  (0.0296044); expected 10714.0 (0.02)
Passed Vit filter:                      4968  (0.00927388); expected 535.7 (0.001)
Passed Fwd filter:                      3953  (0.00737916); expected 5.4 (1e-05)
Initial search space (Z):             535698  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 39.03u 0.22s 00:00:39.25 Elapsed: 00:00:10.55
# Mc/sec: 4685.10
//
